Native T1 is predictive of abnormal myocardial strain in hypertrophic cardiomyopathy

Background Hypertrophic cardiomyopathy (HCM) is an autosomal dominant inherited disease, characterized by myocardial wall thickening in the absence of other etiologies of hypertrophy. Histologically, HCM is characterized by myocyte hypertrophy and disarray with collagen deposition. Native T1 time of the myocardium is increased in the presence of myocardial fibrosis. The purpose of this study was to determine if greater T1 time was associated with abnormal myocardial wall strain.