Structure Elucidation of Fumagillin-Related Natural Products

Fumagillin is currently the only means of treatment of microsporidiosis, which is frequent and fatal in AIDS patients. Results relating to NMR and X-ray crystallographic studies of fumagillin and the structure elucidation of three related compounds are reported. In the main impurity of fumagillin there is an exocyclic double bond instead of the spiroepoxide moiety. The solid-state and solution structures of fumagillin were compared with the conformation of fumagillin complexed to aminopeptidase-2.