Clinical significance of radical cystectomy with extended lymphadenectomy

Objective: To evaluate the prognosis of patients treated with radical cystectomy and exten-ded lymphadenectomy for invasive bladder cancer and to describe the association of the primary bladder tumor grade,stage,lymph node status and lymph node density with clinical outcomes.Methods: A retrospective analysis was done of 32 consecutive cases with bladder cancer who received radical cystectomy and extended lymph node dissection from January 2006 to December 2010 in the Department of Urology,Peking University First Hospital.All the patients were scheduled for the follow-up.The survival data were analyzed with the tumor grade,stage,lymph node status and other factors that might relate to the prognosis by statistics.Results: All the cases were diagnosed as invasive urothelial bladder cancer by preoperative biopsy or TUR-Bt.During the follow-up,6 patients(18.8%) got disease progression,and 4 patients died(12.5%).Overall survival rate was 87.5%.In 32 patients,17 months and 3 year survival rates were(88.7 ± 12.1)% and(81.8 ± 17.0)%,respectively.From the tumor grade point of view,6 patients belonged to G2,and 26 cases G3.All deaths were graded G3.G3-class 3-year survival rate was(74.6 ± 23.9)%(P 0.05,compared with G2).From the analysis of stage,T1 and T2 stages had no death during the follow-up.The 17-month survival rate of T3 group was(60.0 ± 42.9)%,the 8-month survival rate of T4 group was(87.5 ± 22.9)%.There were 9 patients with po-sitive lymph nodes(28.1%) and 23 with negative in(71.9%).The number of dissection lymph nodes was from 7-50(average 22.8).The 17-month survival rate of patients with positive lymph node was(50.0 ± 44.6)%.The 3-year survival rate of patients with negative lymph node was(92.3 ± 14.5)%(P0.05).The 3-year survival rate of patients with lymph node density less than 20% was(88.8 ± 15.4)%.The 8-month survival rate of patients with lymph node density greater than 20% was(66.7 ± 53.3)%(P0.05).Conclusion: Radical cystectomy with extended lymph node dissection can improve the prognosis of patients with invasive bladder cancer.Tumor stage,lymph node status and lymph node density are closely related to the patient's survival.