Chromogranin A expression in plasma of critically ill patients

Risk assessments of patients should be based on objective variables, such as biological markers that can be measured routinely. Such a prediction remains a difficult challenge. The acute response to stress causes the release of catecholamines from the chromaffin cells of the adrenal medulla accompanied by numerous proteins, peptides such as chromogranin A (CGA) and its natural fragments. To date, no study has evaluated the prognostic value of CGA in critically ill ICU patients.