Facile One-Pot Synthesis of 2,3,5-Substituted 1,2,4-Oxadiazolines from Nitriles in Aqueous Solution
2005
Alkyl/aryl amidoximes, prepared from the corresponding nitriles and N-alkylhydroxylamines, have readily undergone consecutive Michael additions to electron-deficient alkynes and provided highly substituted 1,2,4-oxadiazolines in good yields in homogeneous aqueous solution.
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