pH-Dependent Dissolution in Vitro and Absorption in Vivo of Weakly Basic Drugs: Development of a Canine Model

Rong Zhou,Paul Moench,Christopher L. Heran,Xujin Lu,Neil R. Mathias,Teresa N. Faria,Doris A. Wall,Munir A. Hussain,Ronald L. Smith,Duxin Sun

pH-Dependent Dissolution in Vitro and Absorption in Vivo of Weakly Basic Drugs: Development of a Canine Model

2005

Rong Zhou
Paul Moench
Christopher L. Heran
Xujin Lu
Neil R. Mathias
Teresa N. Faria
Doris A. Wall
Munir A. Hussain
Ronald L. Smith
Duxin Sun

Purpose. The aim of this research was to develop a pH-dependent canine absorption model for studying pH effect on both dissolution in vitro and pharmacokinetics in vivo using the weak bases ketoconazole and dipyridamole as model drugs.

Keywords:

Absorption (pharmacology)
Dipyridamole
Medicinal chemistry
In vivo
Dissolution
Bioavailability
Ketoconazole
In vitro
Biochemistry
Chemistry
Pharmacokinetics
Chromatography

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