related microRNA-21 mismatch repair methods and in colorectal cancer

A composition of matter for use in the treatment of colorectal cancer (CRC) in a patient having decreased expression of hMSH2 protein (protein complex recognition mismatch repair (MMR)) and responds to treatment with 5- fluorouracil, the composition comprising: an effective amount of miR-21 antisense and a pharmaceutically acceptable formulation thereof, wherein miR-21 is SEQ ID. No.12.