Multicentric evaluation of the homogeneous LDL-cholesterol Plus assay: Comparison with beta-quantification and Friedewald formula
2008
Abstract Objectives To evaluate the analytical and clinical performance of a new version of the LDL-C Plus assay and compare it with the beta-quantification (BQ) method in a multicenter study. Design and methods Direct LDL-C was measured in 169 fresh pooled samples and in 830 clinical samples with known LDL-C by BQ. The reactivity of lipoproteins and the effect of hemoglobin, bilirubin and chylomicrons (CM) were studied. Results Direct LDL-C total imprecision was 0.57. Conclusions LDL-C Plus assay represents a valid alternative to BQ for clinical laboratories.
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