American Society of Transplantation and Cellular Therapy Series, #4: Cytomegalovirus Treatment and Management of Resistant or Refractory Infections after Hematopoietic Cell Transplantation.

The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy (ASTCT) partnered with its Transplant Infectious Disease Special Interest Group (TID-SIG) to update its 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). A new approach was taken, with the goal of better serving clinical providers by publishing each standalone topic in the infectious diseases series as a concise format of frequently asked questions (FAQs), tables, and figures. Adult and pediatric infectious diseases and HCT content experts developed and answered these FAQs. Topics were finalized with harmonized recommendations that were made by assigning an A through E strength of recommendation paired with a level of supporting evidence graded I through III. The fourth topic in the series focuses on the management and treatment of cytomegalovirus (CMV)-resistant/refractory (R/R) infections. The diagnosis, definitions of R/R CMV, risk factors, virologic genotypes, and treatment algorithms are reviewed.