Epidemiologic Investigation in 697 Cases of Acute Glomerulonephritis

Objective To explore the epidemiology,clinical characteristics and prognosis of acute glomerulonephritis(AGN).Methods The study was designed to investigate the admission rate and diversity of 697 children with AGN in hospitalized patients from Jan.1996 to Dec.2005,and analyze epidemiology,etiology,clinical characteristics and prognosis.Results Six hundred and ninety-seven cases of AGN accounted for 3.5‰ of the hospitalized children and 18.3% of urinary disease children.The cases were shown in each month of the year,mainly in Nov.,Dec.,and Jan.,least in Aug.Twenty-four(3.4%)cases of AGN were detected among first degree relatives,31(4.4%)and 2(0.3%)cases among the second and the third degree relatives.Of 697 cases 405(58.1%)were induced by respiratory infection,194(27.8%)skin infection and 98(14.1%)without determined infection.The time from respiratory infection and skin infection to AGN was(11.2±5.9)days to(19.1±8.4)days.Etiology analysis showed that the positive detection rate of antistreptolytin O(ASO)was 66.7%,Coxsackie(Cox)virus 53.6%,while 57.8% with ASO positive in Cox virus cases.The positive detection rate of mycoplasma was 0,18.8%,35.0% in 2003,2004,2005.Of 697 cases,21(3.0%)were complicated with serious circulation hyperaemia,36(5.2%)with hypertensive encephalopathy,42(6.0%)with acute renal insufficiency.Complete remission was noted in 507 out of(72.7%)while 1(0.1%)died of AGN.Conclusions During the past 10 years,streptoc coccus infection was still the main cause of AGN.The incidence was declining for the hospitalized patients with AGN,but there was no improvement on the incidence of acute renal insufficiency.