Synthesis and biological properties of 3-[(Z)-2-(1,2,3-Thiadiazolyl)ethenyl]-substituted cephalosporins and related compounds: new oral cephalosporins
1993
A series of cephalosporins possessing a [(Z-2-(1,2,3-thiadiazolyl)ethenl] moiety at C-3 were synthesized and their biological properties were examined. SC-002 (1a) exhibited excellent activity against both Gram-positive and Gram-negative bacteria. The ester SC-004 (1b) showed good bioavailability after oral administration in mice and rats.
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