MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis.

Abraham L. Moure,Gagandeep Narula,Flavia Sorrentino,Adama Bojang,Clement K. M. Tsui,Carine Sao Emani,Esther Porras-De Francisco,Beatriz Díaz,María José Rebollo-López,Pedro Alfonso Torres-Gomez,Eva Maria Lopez-Roman,Isabel Camino,Patricia Casado Castro,Laura Guijarro-Lopez,Fátima Ortega,Lluis Ballell,David Barros-Aguirre,Modesto J. Remuiñan Blanco,Yossef Av-Gay

MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis.

2020

Abraham L. Moure
Gagandeep Narula
Flavia Sorrentino
Adama Bojang
Clement K. M. Tsui
Carine Sao Emani
Esther Porras-De Francisco
Beatriz Díaz
María José Rebollo-López
Pedro Alfonso Torres-Gomez
Eva Maria Lopez-Roman
Isabel Camino
Patricia Casado Castro
Laura Guijarro-Lopez
Fátima Ortega
Lluis Ballell
David Barros-Aguirre
Modesto J. Remuiñan Blanco
Yossef Av-Gay

Screening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis identified 1, a thioalkyl-benzoxazole hit. Biological profiling and mutant analysis revealed that this compou...

Keywords:

Intracellular
Mycobacterium tuberculosis
Mutant
Biochemistry
Chemistry
Prodrug

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