Evaluation of effective doses of hepatitis B immunoglobulin to eliminate hepatitis B surface antigen from infected neonates
2012
Objective To determine the effective dose of hepatitis B immunoglobulin (HBIG) for clearing maternally-transmitted hepatitis B virus (HBV) fiom a newborn.Methods Full-term neonates born to HBV-infected mothers were tested for hepatitis B surface antigen (HBsAg) and HBV DNA in venous blood,Individuals with positive results within two hours after birth were selected for study,and divided among two treatment groups: research group receiving HBIG continually adjusted to quantitative levels of neonatal HBsAg and HBV DNA levels; control group receiving standard HBIG 200IU dose.All neonates were also treated with 10 micrograms of recombinant vaccine.The decreases in HBsAg and HBV DNA over 12 months were comparatively analyzed between the two treatment groups.Results The two treatment groups (HBIG adjusted vs.standard) were statistically similar in Apgar score (9.38 ± 0.49 vs.9.37 ± 0.48),neonate body weight (3458.67 + 374.93 vs.3558.61 ± 322.85 g),maternal age (26.33 ± 3.63 vs.25.33 ± 3.03),and initial HBsAg and HBV DNA levels (rank sum test Z=1.381,and Z=0.700,respectively) (all,P> 0.05).Successful clearance of HBV infection within 12 months was achieved in significantly more neonates in the HBIG adjusted therapy group than in the standard therapy group (82.8% vs.57.4%; x2 =9.696,P < 0.05).Condusion Adjusting the neonatal HBIG dose according to HBsAg and HBV DNA levels can improve the success rate of clearing maternally-transmitted HBV.
Key words:
Hepatitis B virus; Hepatitis B e antigens; Therapy
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