The esophageal motility characteristics and levels of brain-gut peptide in patients with refractory globus

Objective To compare the esophageal motility and the levels of brain-gut peptide between refractory globus patients and non-refractory globus patients. Methods All subjects underwent high-resolution manometry (HRM) and were detected the levels of brain-gut peptide, which were compared the differences between refractory globus patients and non-refractory globus patients. Results Refractory globus patients had higher upper esophageal sphincter (UES) resting press [(94.97±42.08)mmHg] compared with non-refractory globus patients [(73.91±23.47)mmHg, t=2.359, P 0.05). The level of NPY was lower in refractory globus patients [(626.26±16.60)ng/L] than that in non-refractory globus patients [(641.35±17.45)ng/L (t=2.528, P 0.05). Conclusion Compared with non-refractory globus patients, refractory globus patients have higher UES resting pressure, higher level of SP and lower level of NPY. Key words: Globus; Esophageal sphincter, upper; Calcitonin gene-related peptide; Neuropeptide Y; Substance P