Effect of Hydrocortisone on Oxidative Degradation of Hexobarbital and Ethylmorphine
1980
In experiments on albino rats of both sexes it has been established that hydrocortisone applied in a single dose of 50mg/kg i.p. inhibits hexobarbital oxidase and ethylmorphine-N-demethylase and applied repeatedly in a dose of 10 mg/kg increases the activity of both enzymes. In castrated male rats the enzyme-inhibiting action of the single dose of hydrocortisone is much reduced, while its enzyme-inducing action on repeated application remains the same (the two effects are evaluated by the hexobarbital sleeping time).
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