Multidisciplinary team for the diagnosis and treatment of 2 cases of primary intestinal yolk sac tumor

Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, thediagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologicand immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of thempreoperatively had an elevated serum alpha fetoprotein (AFP) level (1210 ng/mL). The tumors are located in the intestine andimaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopicexamination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically,tumors cells of both cases were positive for SALL4, AFP, pan-cytokeratin (AE1/AE3), and glypican-3. Simultaneously, a stain forEMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology,immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine.