Synthesis and Evaluation of N-Substituted 1-(5-Fluoro-2-pyrimidinyl) piperazine Derivatives as Potential anti-Ischemic Agents.

Abstract A number of N-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives were prepared and evaluated for binding to sigma and serotonin 5-HT 1A and 5-HT 2 receptor subtypes as well as for their protection against nitrogen anoxia-induced lethality in rats. Although various compounds exhibited good binding affinity and/or anti-anoxic effects, there was no obvious correlation between their receptor binding and in vivo effects.