A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue

Eva Zsuzsanna Hoseth,Thor Ueland,Ingrid Dieset,Rebecca Birnbaum,Joo Heon Shin,Joel E. Kleinman,Thomas M. Hyde,Ragni Mørch,Sigrun Hope,Tove Lekva,Aurelija Abraityte,Annika E. Michelsen,Ingrid Melle,Lars T. Westlye,Torill Ueland,Srdjan Djurovic,Pål Aukrust,Daniel R. Weinberger,Ole A. Andreassen

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue

2017

Eva Zsuzsanna Hoseth
Thor Ueland
Ingrid Dieset
Rebecca Birnbaum
Joo Heon Shin
Joel E. Kleinman
Thomas M. Hyde
Ragni Mørch
Sigrun Hope
Tove Lekva
Aurelija Abraityte
Annika E. Michelsen
Ingrid Melle
Lars T. Westlye
Torill Ueland
Srdjan Djurovic
Pål Aukrust
Daniel R. Weinberger
Ole A. Andreassen

Objective: A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to the pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) and related comorbidities. We investigated the relative distribution of TNF-related molecules in blood and dorsolateral prefrontal cortex (DLPFC) in these disorders.

Keywords:

Psychiatry
Working memory
Psychology
Tumor necrosis factor alpha
Schizophrenia
Neuroscience
Bipolar disorder
Gene expression
Blood cell
Dorsolateral prefrontal cortex
Whole blood
Pathogenesis
Proinflammatory cytokine

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