99. Plasma markers of inflammation are elevated in intermittent explosive disorder and as a function of aggression in human subjects

Behavior can influence immune function, inflammatory activity, and psychological functioning; these relationships are often bi-directional. Aggressive behavior is associated with elevations in inflammatory mediators in animals, but few studies have examined these connections in humans. The present study explored relationships between aggressive behavior and serum levels of interleukin-6 (IL-6), soluble interleukin-1B receptor type II (IL1BrII), and C-reactive protein (CRP) in patients with Intermittent Explosive Disorder (IED), controls with Axis I and/or Axis II, disorders (Psychiatric Controls: PC), and subjects with no evidence of psychopathology (Healthy Controls: HC). Inflammatory markers were highly correlated with aggressive behavior, and impulsivity and aggression were highly related in all subjects ( p p s  p s