Risk of colistin underdosing in patients with acute kidney injury-results of a single and multiple dose PK study in critically ill patients undergoing extended dialysis

Objectives: Due to the lack of new antibiotics for the treatment of critically ill patients with multidrug-resistant bacteria, interest on “old” antibiotics like Colistin re-emerged. Dosing of Colistin in critically ill patients undergoing renal replacement therapy is based on scarce data. We aimed to perform a prospective clinical study on dosing of intravenous Colistin in critically ill patients with AKI undergoing extended dialysis to develop dosing recommendations for this patient cohort.