Photorefractive Keratectomy in Megalophthalmos Anterior

PURPOSE: To evaluate the results of photorefractive keratectomy (PRK) for the correction of myopia and myopic astigmatism in megalophthalmos anterior. METHODS: Four eyes of two brothers with megalophthalmos anterior were treated with PRK. In patient 1, best spectacle-corrected visual acuity (BSCVA) was 20/20 in both eyes with a refraction of -4.50 -4.50 x 180° in the right eye and -3.75 -3.00 x 175° in the left eye. In patient 2, BSCVA was 20/25 in both eyes with a refraction of -4.25 x 166° in the right eye and +0.50 -4.00 x 175° in the left eye. RESULTS: Topographic map, slit-lamp, ultrasound biomicroscopy, and postoperative course (no progression), supported with vectorial analysis, demonstrated megalophthalmos anterior. During 24-month follow-up, mild haze was observed and BSCVA was maintained. CONCLUSIONS: Myopia and astigmatism are often observed in this type of nonprogressive corneal dysgenesis. Based on this fact and our results, we recommend PRK in cases of megalophthalmos anterior.