Primary Neuroendocrine Tumor of Breast: Report of a Rare Case with Review of Literature

The neuroendocrine tumors NETs are basically derived from the neuroendocrine cell which secrete different types of amines and peptides The neuroendocrine cell is very rare in breast carcinoma of less than In the breast carcinoma Primary neuroendocrine tumors are a heterogeneous series with of cells having positive immunoreactivity to neuroendocrine markers A case of years woman with a lump in her right breast She was evaluated for surgery and modified radical mastectomy MRM was done Grossing of specimen showed two tumors in retro areolar and lower outer quadrant respectively Histopathology revealed neuroendocrine tumor of the breast All eighteen lymph nodes showed reactive lymphoid hyperplasia Immunohistochemical report showed cells were positive for synaptophysin chromogranin neuron specific enolase NSE and Ki The estrogen receptor progesterone receptor and HER Neu were negative No mucin production was seen in this patient Neuroendocrine tumors in the breast are mostly malignant Mucinous carcinomas of breast have association with neuroendocrine differentiation but in this case although having neuroendocrine differentiation is not associated with mucin production Here we present a case of NET of the breast where tumor cells were non reactive for ER Estrogen Receptor PRs Progesterone Receptors and cells show frequent mitotic figures The review accompanying this case report is provide an overview of all the cases of primary neuroendocrine tumor of the breast published in the literature and detailed information regarding classification epidemiology clinical and histological diagnosis criteria histogenesis surgical and adjuvant treatment as well as prognosis