Effects of Locally Delivered Doxycycline on Periodontal Clinical Parameters and Gingival Crevicular Fluid Matrix Metalloproteinase-8
2016
Background: The aim of this study was to evaluate the effect
of local doxycycline (Atridox) as an adjunctive to non-surgical
periodontal treatment on clinical parameters and gingival crevicular
fluid (GCF) levels of matrix meatalloproteinase-8 in patients with
chronic periodontitis.
Materials and Methods: A double-blind spilt mouth; randomized,
controlled clinical trial was conducted in 30 patients with moderate
to severe chronic periodontitis. Two teeth were selected from
similar quadrants with a probing pocket depth ≥5 mm, and
randomly allocated into test and control groups. The control
group was treated with scaling and root planning (SRP) only;
the test group was treated with SRP and received adjunctive
local Atridox. Periodontal clinical parameters were recorded and
matrix metalloproteinases-8 (MMP-8) level in GCF samples were
determined using the enzyme-linked immunosorbent assay at
baseline and 1, 3 months.
Results: Statistically significant reduction in probing depth and
clinical attachment level and GCF MMP-8 was found in test and
control groups compared with baseline, test group showed a
significant reduction in clinical parameters and GCF MMP-8 level
compared with the control group.
Conclusion: Local delivery doxycycline (Atridox) combined with
SRP significantly improved the clinical parameters and decreased
GCF level of MMP-8.
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