Study of Chlorophytum arundinaceum against experimental gastric ulcer

AbstractThe current study was designed to investigate the effect of a 50% alcohol extract of Chlorophytum arundinaceum. Baker (CAE) against ethanol-induced pylorus ligation and cold stress–induced experimental gastric ulcer. The CAE was given at the dose of 100 mg/kg, p.o., in all the models, and results of those were compared with that of animals treated with omeprazole 20 mg/kg, p.o. (reference standard). Ulcer index was a common evaluating parameter in all the models. In the pylorus ligation model, acid secretory parameters (total acid, pepsin activity, and total acid output) and mucoprotective parameters (total carbohydrate, total protein, and mucin activity) were studied. In addition, lipid peroxidation and antioxidant activity were specifically studied in cold stress–induced gastric ulcer model. Effects on vascular permeability as well as gastric emptying were also studied. CAE has shown significant protection in gastric ulceration as evident from reduction (p < 0.05) in ulcer index in all the model...