Intramural Duodenal Haematoma After Upper Gastrointestinal Endoscopic Biopsy in a Bone Marrow Transplant Recipient

s / Biol Blood Marrow Transplant 19 (2013) S279eS312 S302 Fisher's exact test. Disease free (DFS) and overall survival (OS) were estimated using Kaplan-Meier methods, and timeto-relapse and non-relapse mortality (NRM) were estimated using cumulative incidence functions. Cox regression was used to further investigate the association between chimerism and the risk of NRM adjusted for key covariates. Results: Of 161 patients identified, 96 were disease free and had PB TC chimerism at 3 month Table 1 lists transplant characteristics and outcomes. PB TC MC was observed in 64 (66%) at 3 month There was no difference in chimerism based on disease, stem cell source, HLA-match, donorrecipient gender pairing, or conditioning regimen. Relapse and DFS were not different between the MC and full donor chimerism groups. However, NRM was significantly higher (P-value 0.001) and OS was significantly lower (P-value 0.01) in the full donor chimerism group at 2 years. Using Cox regression, the association between chimerism and NRM remained after adjusting for DLI, disease, conditioning regimen and donor-recipient sex (P value 0.03). Analysis of 6 month PB TC chimerism also showed patients withMC in the PB at 6 months had less NRM and improved OS than patients with full donor chimerism. Conclusions: In this analysis of PB TC chimerism following TCD transplant, both NRM and OSwere significantly better in patients with MC. These data suggest that DLI for the conversion of MC to full chimerism may be unnecessary.