Novel Multicomponent Domino Approach to 2,5-Bifunctionalized Five-Membered Cyclic Nitrones

Multicomponent reaction of 2,2-dimethylpenta-3,4-dienal oxime was studied. Optimum reaction conditions leading to a new family of 5-membered cyclic nitrones were found. This reaction offers direct access to target structures in a single synthetic step that involves introduction of various functional groups at positions 2 and 5 of the nitrone moiety. The reaction scope and limitations were evaluated. All products were isolated and fully characterized.