NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

Li Jiang,Changwei Shao,Qijia Wu,Geng Chen,Jie Zhou,Bo Yang,Hairi Li,Lan-Tao Gou,Yi Zhang,Yangming Wang,Gene W. Yeo,Yu Zhou,Xiang-Dong Fu

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

2017

Li Jiang
Changwei Shao
Qijia Wu
Geng Chen
Jie Zhou
Bo Yang
Hairi Li
Lan-Tao Gou
Yi Zhang
Yangming Wang
Gene W. Yeo
Yu Zhou
Xiang-Dong Fu

The lncRNA NEAT1, a key component of paraspeckles, interacts with RNA-binding proteins, including NONO and PSF, and affects global pri-miRNA processing by recruiting the Drosha–DGCR8 Microprocessor.

Keywords:

MiRNA processing
Paraspeckles
Computational biology
Biochemistry
RNA-binding protein
Biology
lncrna neat1
Biogenesis
Long non-coding RNA
RNA
microRNA

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