STEREOSELECTIVE REDUCTION OF THE ACTIVE SUBSTANCE OF THE MEDICINAL PREPARATION DIMEBON TO THE CORRESPONDING cis - AND trans -1,2,3,4,4a,9b-HEXAHYDRO DERIVATIVES

Convenient preparative methods have been developed  for the reduction of the active substance of the medicinal preparation Dimebon (2,8-dimethyl-5-[2-(6-methylpyrid-3-yl)ethyl]-1,2,3,4-tetrahydro-γ-carboline) to the corresponding racemic cis -  and trans -1,2,3,4,4a,9b-hexahydro derivatives, distinguished by a high degree of stereoselectivity. The structures of the obtained diastereomeric hexahydro-γ-carbolines were confirmed by various physicochemical methods, including X-ray structural analysis. How to Cite Alekseyev, R. S.; Ivanov, A. S.; Kurkin, A. V.; Yurovskaya, M. A.  Chem. Heterocycl. Compd. 2010 , 46 , 1116. [ Khim. Geterotsikl. Soedin. 2010 , 1384.] For this article in the English edition see DOI 10.1007/s10593-011-0658-7