Radiation doses obtained from 99mTc-labelled human milk fat globule monoclonal antibodies

Abstract Human milk fat globule (HMFG) monoclonal antibodies labelled with 123 I and 111 In are used for the diagnosis of ovarian and breast cancer. Methods have been developed to label HMFG with 99m Tc and this study reports on the subsequent radiation dose delivered. The 99m Tc HMFG1 distribution was obtained in 5 normal female baboons up to 71 h after administration. The liver, kidneys, bladder and whole body were identified as source organs and total absorbed doses for the target organs were 0.054 (kidneys), 0.013 (liver), 0.140 (bladder), 0.010 (ovaria), 0.004 (bone marrow), 0.002 (thyroid), 0.003 (heart wall), 0.017 (uterus) and 0.005 mGy/MBq (whole body). The effective dose was 0.014 mSv/MBq.