Exploring genetic suppression interactions on a global scale
2016
The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen et al. generated a large-scale suppression network in yeast. The data set reveals a set of general properties that can be used to predict suppression interactions. Furthermore, the study provides a template for extending suppression studies to other genes or to more complex organisms.
Science , this issue p. [599][1]
[1]: http://www.sciencemag.org/content/354/6312/aag0839.full
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