IL7R overexpression in adult acute lymphoblastic leukemia is associated to JAK/STAT pathway mutations and identifies patients who could benefit from targeted therapies

The IL7 receptor α chain, encoded by the IL7R gene, heterodimerizes with the IL-2Rγ (common gamma) chain to form the IL7 receptor, or with the cytokine receptor-like factor 2 (CRLF2) for the thymic...