GW29-e0082 Chronic Intermittent Hypoxia Induces Endothelial Insulin Resistance in vivo and in vitro

Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is an independent risk factor for cardiovascular disease and type 2 diabetes and is correlated with insulin resistance. Insulin stimulates production of nitric oxide (NO) in vascular endothelial cells through the IRS