Взаимосвязь основных показателей кальциевого и липидного обмена с атеросклерозом коронарных артерий

Aim. To amine the relationship between indicators of calcium and lipid metabolism and to assess the impact of these markers on the instability of atheroscleroticlesions in coronary arteries. Materials and methods. 106 men (46-79years) were divided into control (without coronary heart disease) and main group with angiographically verified coronary atherosclerosis. The main group was divided into 2 subgroups. In thefirstsubgroup were included 36 men with stable coronary plaques, in the secondgroup 40 men with unstable atherosclerotic plaques in the coronary arteries. Serum calcitonin, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), alkaline phosphatase, calcium, magnesium and phosphorus were determined. Statistical analysis was performed using the licensed version of the SPSS program (13.0). Results. Patients of the main group had higher levels of calcium (2.4 + 0.0 mmol/l), magnesium (0.8 + 0.0 mmol/l), calcitonin (2.2 + 0.7 pg/ml), alkaline phosphatase (165.9+4.5 U/l) and triglycerides (177.6+15.0 mg/dl), and lower HDL-C levels (34.5 + 1.2 mg/dl). In our study changes of LDL-C and calcitonin levels were associated with the presence of unstable atheroscleroticplaques in coronary arteries. TC levels did notdiffer significantly between groups. There were correlations between TC and calcium levels (r 0.402, p 0.004), TC and LDL-C levels (r 0.771, p = 0.001) and TC and TG levels (r 0.262, p = 0.02); a correlation between calcium and LDL-C levels (r =0.380, p-0.004). We found also a relation between phosphorus and TG levels (r 0.436, p 0.001) and phosphorus and HDL-C levels (r -0.280, p 0.03); a relation between alkaline phosphatase and magnesium levels (r 0.331,p 0.006). The calcitonin level depended on TG (r 0.433, p 0.02) and LDL-C (r 0.442, p = 0.02) levels; there was a connection between calcitonin and HDL-C levels also (r -0.682, p 0.01). Conclusion. Our data suggest that there is a link between lipid and calcium metabolism and the development of coronary atherosclerosis andpossibility of atheroscleroticlesions destabilisation.