Peritoneal Transport, Residual Kidney Function and Chronic Inflammation in Peritoneal Dialysis Patients

Background: Both peritoneal transport characteristics and residual kidney function (RKF) are closely related to the outcome of peritoneal dialysis (PD) patients. In the present study, we examine the prevalence of chronic inflammation and study the relationship between peritoneal clearance character, RKF chronic inflammation and clinical features of PD patients. Methods: We studied 100 clinically stable PD patients and their demographic data, peritoneal transport rate (PTR) and RKF were reviewed and recorded. Biochemical data and serum high sensitivity C-reactive protein (hsCRP) were measured. Correlation studies and multiple regression analysis were performed among variables. Results: Patients with high PTR had longer PD duration, higher total creatinine clearance and lower serum albumin. Lack of RKF was associated with longer PD duration, lower total creatinine clearance and higher hsCRP. Mare inflamed patients had a lower amount of urine and lower renal clearance. The PTR correlated negatively with serum albumin and urine amount. Body mass index and cholesterol level were independent markers of the hsCRP level. Conclusions: Peritoneal permeability increased with PD duration and was associated with a lower albumin level. A decrease in RKF was related to demotion of hsCRP level. Both body mass index and dyslipidemia were independently relevant with chronic inflammation in PD patients.