Quality Assessment and Comparative Study of different Marketed Brands of Metformin

Metformin, chemically N, N-dimethylimidodicarbonimidic diamide belonging to biguanides class is an orally effective drug of choice for the treatment of Type 2 diabetes mellitus which basically acts by activating enzyme AMPK which further control carbohydrate metabolism by reducing intestinal glucose absorption, hepatic glucose production and escalating insulin sensitivity. Various generic brands of metformin are available in the market which makes it difficult to select which brand can be used and whether it will have the same efficacy as that of ethical brand, therefore, the present study has been designed to evaluate the quality control parameters of different selected brands of metformin. The results indicated that all the selected drugs (whether branded or generic) fulfilled the required specifications and thus can be used freely as a substitution of each other.