Nedaplatin combined with synchronous three-dimensional conformal radiotherapy in treatment of esophageal cancer.

Objective To evaluate the efficacy and safety of nedaplatin(NDP) and combined with synchronous three-dimensional conformal radiotherapy in the treatment of esophageal cancer.Methods Three-dimensional conformal radiotherapy was administered in 43 cases of advanced esophageal squamous cell carcinoma,with a total dose of(60～66) Gy/(30～33) Fx.Combination chemotherapy was NDP40 mg/m2,weekly.Results Of 43 patients in this trial,the response and toxicity of 41 cases were available to be evaluated.The response rate was 70.7% after 3 months of follow up.The most common adverse events were myelosuppression and radiation esophagitis.Conclusion Three-dimensional conformal radiotherapy was combined with nedaplatin can improve the lately effective rate of patients with esophageal carcinoma.The toxicities for the patients are tolerable.