Molecular modelling and Docking studies on shrimp vitellogenin receptor and ligand target mediated delivery system

Viral pathogens of shrimp such as the white spot syndrome virus (WSSV), Yellow head virus (YHV), Taura syndrome virus (TSV), Hepatopancreatic parvovirus (HPV), and Monodon Baculovirus (MBV), which are geographically widespread, are major concern in shrimp aquaculture due to the associated huge economic loss . The control of such diseases is a challenging task for the shrimp aquaculture industry. Drug delivery mediated by specific receptor and ligand interaction plays an important role in effective control of diseases. In the present study focus on vitellogenin receptor and ligand interaction for targeted drug delivery for control of MBV infection in black tiger shrimp (Penaeus monodon) was explored by insilico studies. Vitellogenin protein receptor of shrimp P. monodon and ligand molecules sequences were retrieved from public domain. Molecular modeling and docking studies were explored by using online bioinformatics tools. The results suggested that 20-hydroxy ecdysone might be a potential target of vitellogenin receptor for effective targeted drug delivery system for control of monodon baculovirus. © 2011 Universal Research Publications. All rights reserved