Effect of Hyaluronidase on Experimental Hypercholesterolemia in Rabbits and Rats and Atheromatosis in Rabbits

Summary1. Subcutaneous or intravenous injection of hyaluronidase depressed hypercholesterolemia in rabbits and rats. 2. Intraperitoneal injection of hyaluronic acid prevented hypercholesterolemia in nephrotic rats. 3. Hyaluronidase facilitated general lipidoses and aggravated atheromatosis in rabbits. 4. The advisability of indiscriminately lowering the blood cholesterol level in hypercholes-terolemics is questioned. 5. The antihyper-cholesterolemic effect of hyaluronidase was abolished when specific antibodies to the enzyme developed. 6. Endogenous experimental hypercholesterolemia in rabbits does not depend on the presence of the adrenals.