New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain

Abstract We report on the design, synthesis, and in vitro evaluation of new quinoline-5,8-dione and hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum . Of the 15 compounds, 7a – c , 8a , 9b , 11 , and 15 were effective in growth inhibition with IC 50 values of below 5 μM.