A kind of anti-PD-L1 antibody, its medical composition and its use

The invention belongs to oncotherapy and molecular immunology field, it is related to a kind of anti-PD-L1 antibody, its medical composition and its use.In particular it relates to a kind of monoclonal antibody or its antigen-binding fragment, wherein the heavy chain variable region of the monoclonal antibody includes: amino acid sequence is the CDR of SEQ ID NO:1-3；And/or the light chain variable region of the monoclonal antibody includes: amino acid sequence is the CDR of SEQ ID NO:4-6.Monoclonal antibody of the invention specificity specifically can release PD-1 and inhibit to immunity of organism in conjunction with PD-L1 well, activated T lymphocytes.