Roseoferin, a new aminolipopeptide antibiotic complex from Mycogone rosea DSM 12973, structures and biological activities.

In the course of microbiological screening aimed at newantifungal antibiotics promoting the transport of hydrophilic anions such as helianthate to organic solvents1>2\ we disclosed recently Mycogone rosea DSM 12973 as the producer of a strongly antifungal and cytotoxic agent. The complex of at least 16 closely related aminolipopeptide antibiotics named roseoferin (I, Table 1) was chromatographically inseparable but structural assignment of every of these components was possible on the basis of tandem mass spectrometry (ESI-triple quadrupol-CID-MS/MS and ESI-ion-trap-CID-MSn),