Cover Picture: Synthesis and Characterization of PY2- and TPA-Appended Diphenylglycoluril Receptors and Their Bis-CuI Complexes (Eur. J. Org. Chem. 10/2006)

The cover picture shows the superposition of a synthetic model of the dinuclear copper enzyme catechol oxidase over the surface and active site of this enzyme. The model is the bis-CuI complex of a ligand-appended diphenylglycoluril basket. This combines a reactive dinuclear copper site (the CuI ions held by the ligands) for the binding and activation of molecular oxygen with a binding site (the diphenylglycoluril clip) for aromatic substrates to be oxidized. Details on this are discussed in the article by M. C. Feiters et al. on p. 2281 ff.