A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles

Steve Price,Richard Bull,Sue Cramp,Sophie Gardan,Marco Van Den Heuvel,David Neighbour,Susan E Osbourn,Iwan J.P. de Esch,Christoph L. Buenemann

A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles

2004

Steve Price
Richard Bull
Sue Cramp
Sophie Gardan
Marco Van Den Heuvel
David Neighbour
Susan E Osbourn
Iwan J.P. de Esch
Christoph L. Buenemann

A library of 2-guanidinomethyl-4(5)-sulfamoylimidazoles was synthesised in a convergent manner by introducing a sulfonyl chloride group via a trianion electrophilic sulfinylation of suitably protected 2-guanidinomethyl imidazoles.

Keywords:

Electrophile
Combinatorial chemistry
Sulfonyl chloride
Organic chemistry
Imidazole
Chemistry
Guanidine

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