Asymmetric Synthesis of α,α-Diaryl and α-Aryl-α-heteroaryl Alkylamines by Organometallic Additions to N-tert-Butanesulfinyl Ketimines.

Abstract Organometallic addition to tert -butanesufinyl ketimines derived from diaryl and aryl-heteroaryl ketones provided the corresponding α,α-diaryl and α-aryl-α-heteroaryl alkylamines in good yield with high diastereoselectivity. In many cases, imine facial selectivity is reversed on changing the organometallic counterion.