Fasicularin, a novel tricyclic alkaloid from the ascidian Nephteis fasicularis with selective activity against a DNA repair-deficient organism

Abstract A novel tricyclic alkaloid, fasicularin ( 1 ), was isolated from the Micronesian ascidian Nephteis fasicularis . The structure of 1 was elucidated primarily by interpretation of spectral data. Fasicularin was found to be active in a DNA damaging assay.