Influence of Ca doping on ZnFe2O4 nanoparticles magnetic hyperthermia and cytotoxicity study

Abstract The biocompatibility nature of the synthesized nanoparticles (NPs) has exposed a superparamagnetic (SP) behavior with best saturation mass magnetization (Ms) values and monodispersed behavior. All these characteristics are essential, for their importance as nanomedicine in the magnetic hyperthermia (MH) treatment of cancer. The prepared powder samples were validated as capable MH mediators by their heating efficiency as measured by specific absorption rate (SAR) in calorimetric measurements. Three Ca2+ - substituted ZnFe2O4 NPs with different Ca2+ contents, the particle size, and crystallite size of the samples have been prepared. These ideal premises have permitted the investigation of the induction heating aptitudes wholly on the origin of the various chemical compositions. Enhanced magnetic features of prepared NPs initiated us to investigate these systems as capable MH agents. FT-IR spectra confirm that the presence of functional groups and vibrational modes of spinel structure. Composition information of the prepared NPs has been studied by X-ray photoelectron spectroscopy (XPS). The prepared samples have significant Ms values at 15 K (