Abstract 12279: CD40, a Significant Mediator of Hypertensive Renal Injury, Activates Pro-Apoptotic P53 Signaling in Human Renal Proximal Tubule Cells

Background: We have shown clinical evidence that circulating levels of the proinflammatory receptor CD40 contribute to the progression of hypertensive renal disease and that the ligand for CD40 (sC...