FRI0235 Effect of serum uric acid (SUA) on gout flares (GF) and tophi resolution in gout patients. pooled post hoc analysis of clear 1 & clear 2 trials

Background Gout is caused by crystal deposition due to persistent hyperuricemia. EULAR 1 and other guidelines recommend a target sUA of 2 . Objectives To investigate the effects of sUA and target sUA Methods Data of 1213 patients (PT) was pooled from CLEAR trials 3&4 , two randomised, double-blind, placebo-controlled Phase 3 studies that evaluated Lesinurad 200/400 mg daily in combination with allopurinol vs allopurinol. Prophylaxis for flares was given from baseline to month (M) 5. PT who met the sUA target of Results PT with sUA on target Conclusions These results confirm that sUA on target References [1] Richette P, et al. Ann Rheum Dis 2017;76:29−42. [2] Qaseem A, et al. Ann Intern Med2017;166(1):58–68. [3] Saag KG, et al. Arthritis Rheumatol2017;69:203–12. [4] Bardin T, et al. Ann Rheum Dis2017;76:811–20. Disclosure of Interest F. Perez-Ruiz Consultant for: Grunenthal, Menarini, Speakers bureau: Grunenthal, Menarini, P. Richette Consultant for: Grunenthal, Speakers bureau: Grunenthal, R. Karra Employee of: Grunenthal, I. Wild Employee of: Grunenthal, H. Hagedorn Employee of: Grunenthal, P. Kandaswamy Employee of: Grunenthal, T. Bardin Consultant for: Grunenthal