4-heteroaryl-tetrahydroquinolines and their use as inhibitors of protein transfer cholesterol esters (CETP).

1998 
Hetero-tetrahydroquinolines of general formula (I), ** (formula) ** in which A represents cycloalkyl having 3 to 8 carbon atoms or represents a 5- to 7-membered saturated, partially unsaturated or unsaturated, optionally benzofused, with up to 3 heteroatoms from the series S, N and / or O, that in case of a saturated heterocycle with a nitrogen function is optionally also attached via this, and the cyclic systems being abovementioned given if substituted up to 5 times by identical or different halogen, nitro, hydroxy, trifluoromethyl, trifluoromethoxy or by alkyl, acyl, hydroxyalkyl or alkoxy straight chain or branched alkyl having up to 7 carbon atoms respectively, or a group of formula -NR3R4 wherein R3 and R4 are identical or different and denote hydrogen, phenyl or straight or branched chain of up to 6 carbon atoms, or ** (formula) ** a represents a radical of formula D represents aryl of 6 to one 0 carbon atoms which is optionally substituted by phenyl, nitro, halogen, trifluoromethyl or trifluoromethoxy, or represents a radical of formula ** (formula) ** wherein R5, R6 and R9 independently of one another C 3 6 carbon atoms, or represent aryl of 6 to 10 carbon atoms or a 5- to 7-membered, optionally benzo-fused, saturated or unsaturated, mono-, bi- or tricyclic with up to 4 heteroatoms from the series of S, N and / or O, the cycles being, if necessary, in the case of nitrogen-containing rings also via the N function, substituted up to 5 times by identical or different halogen, trifluoromethyl, nitro, hydroxy, cyano mode , carboxyl, trifluoromethoxy, acyl, alkyl, alkylthio, alkylalkoxy, alkoxy or alkoxycarbonyl of up to 6 carbon atoms respectively, aryl or aryl substituted by trifluoromethyl 6 to 10 carbon atoms respectively or an aromatic heterocyclic 5- to 7 esl soaps, optionally benzo-fused, with up to 3 heteroatoms from the series of S, N and / or O, and / or a group of formula ** (formula) **.
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