QSAR study of quinoline metanols with antimalarial activity against Plasmodium falciparum

A QSAR model was formed with total of twenty five 4-position quinoline methanol antimalarials that inhibit the growth of W2 strain of the Plasmodium falciparum. The DRAGON software was used to produce descriptors. The MobyDigs software was used to build a QSAR model, which is composed of three descriptors, RDF065m, Mor15e, G1m. The QSAR model satisfies all the criteria required for validation, indicating that the model is robust and good predictive ability. Biological activity of twenty three newly modeled compounds were calculated using the QSAR model. Five newly modeled compounds are predicted to have higher biological activities than any one of the observed. They are suggested for synthesis.